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That's for all this post today. I hope this has stimulate your hunger to know more about McArdle Disease. Do contain your hunger pangs and we will be feeding you with more information next week.
Welcome to MacDonald
This is our special menu for the branch located in Ngee Ann Polytechnic, School of Life Science & Chemical Technology, Blk83 B1-01.
May I have your order please?
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Alright, I see that you have chosen our restaurant best course meal. (McArdle served with Medical Biomolecular Chemistry knowledge). That will be free for you as long as you keep a lookout to this space every Tuesday as we will be serving you all new interesting and mouth watering facts on the disease state called: McArdle disease, or also known as muscle phosphorylase (myophosphorylase) deficiency.
So are you ready for the appetizers?
Glycogen storage disease type V (also known as GSDV or McArdle disease) is an inherited disorder caused by an inability to break down a complex sugar called glycogen in muscle cells. A lack of glycogen breakdown interferes with the function of muscle cells.
People with GSDV typically experience fatigue, muscle pain, and cramps during the first few minutes of exercise. Exercise such as weight lifting or jogging usually triggers these symptoms in affected individuals. The discomfort is generally alleviated with rest. If individuals rest after brief exercise and wait for their pain to go away, they can usually resume exercising with little or no discomfort. Prolonged or intense exercise can cause muscle damage in people with GSDV.
About half of people with GSDV experience breakdown of muscle tissue (rhabdomyolysis). In severe episodes, the destruction of muscle tissue releases a protein called myoglobin, which is filtered through the kidneys and released in the urine (myoglobinuria). Myoglobin causes the urine to be red or brown. This protein can also damage the kidneys, and it is estimated that half of those individuals with GSDV who have myoglobinuria will develop life-threatening kidney failure.
The signs and symptoms of GSDV can vary significantly in affected individuals. The features of this condition typically begin in a person's teens or twenties, but they can appear anytime from infancy to adulthood. In most people with GSDV, the muscle weakness worsens over time; however, in about one-third of affected individuals, the muscle weakness is stable. Some people with GSDV experience mild symptoms such as poor stamina; others do not experience any symptoms.
About half of people with GSDV experience breakdown of muscle tissue (rhabdomyolysis). In severe episodes, the destruction of muscle tissue releases a protein called myoglobin, which is filtered through the kidneys and released in the urine (myoglobinuria). Myoglobin causes the urine to be red or brown. This protein can also damage the kidneys, and it is estimated that half of those individuals with GSDV who have myoglobinuria will develop life-threatening kidney failure.
The signs and symptoms of GSDV can vary significantly in affected individuals. The features of this condition typically begin in a person's teens or twenties, but they can appear anytime from infancy to adulthood. In most people with GSDV, the muscle weakness worsens over time; however, in about one-third of affected individuals, the muscle weakness is stable. Some people with GSDV experience mild symptoms such as poor stamina; others do not experience any symptoms.
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That's for all this post today. I hope this has stimulate your hunger to know more about McArdle Disease. Do contain your hunger pangs and we will be feeding you with more information next week.
Have a great week ahead!
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